Observation of the effect of cefuroxime combined with methylprednisolone in the treatment of chronic obstructive pulmonary disease with emphysema
10.3760/cma.j.issn.1008-6706.2017.10.020
- VernacularTitle:头孢呋辛联合甲泼尼龙治疗老年慢性阻塞性肺疾病合并肺气肿的疗效观察
- Author:
Yonghua ZHANG
;
Shuifang CHEN
;
Minzhen ZHANG
;
Shiyuan CHEN
- Keywords:
Chronic obstructive pulmonary disease;
Pulmonary emphysema;
Antibiotics;
Glucocorticoid;
Aged
- From:
Chinese Journal of Primary Medicine and Pharmacy
2017;24(10):1515-1519
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe and analyze the clinical effect of cefuroxime combined with methylprednisolone in the treatment of elderly patients with chronic obstructive pulmonary disease(COPD) complicated with pulmonary emphysema.Methods 92 COPD patients complicated with pulmonary emphysema were selected as study objects,and they were randomly divided into observation group and control group.46 cases in the control group were treated with antibiotic treatment, and 46 cases in the observation group were treated with cefuroxime combined with methylprednisolone.The clinical curative effect, pulmonary function, blood gas index and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 91.30%, which was significantly higher than 76.09% of the control group (x2=8.476,P<0.05).The pulmonary function indices including FVC%,FEV1,FEV1%,MVV levels in the observation group were higher than those in the control group (t=2.657,3.610,2.413,2.359,all P<0.05).The PaO2 level in the observation group [(80.3±2.8)mmHg] was higher than (74.1±3.8)mmHg in the control group, the PaCO2 level in the observation group [(34.0±1.1)mmHg] was significantly lower than (40.2±2.2)mmHg in the control group, the differences were statistically significant (t=3.021,3.952,all P<0.05).The incidence rate of adverse reactions of the observation group was 6.52%,which of the control group was 10.87%, the difference was not significant (x2=1.363,P>0.05).Conclusion In elderly COPD patients with emphysema, using cefuroxime combined with methylprednisolone therapy can effectively alleviate the clinical symptoms, improve lung function and blood gas index, and has less adverse reactions, higher safety and high clinical application value.
