Association between let-7 gene rs10877887 polymorphism and cancer risk in the Chinese population:A meta-analysis
10.3969/j.issn.1673-4130.2017.08.004
- VernacularTitle:中国人群let-7基因rs10877887多态性与癌症风险相关性的Meta分析
- Author:
Guiping XU
;
Qing ZHAO
;
Ding WANG
;
Lijun ZHANG
;
Wenyue XIE
;
Hua ZHOU
;
Shizhi CHEN
;
Lifang WU
- Keywords:
let-7;
rs10877887;
polymorphism;
cancer;
meta-analysis
- From:
International Journal of Laboratory Medicine
2017;38(8):1019-1022
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relationship between the let-7 rs10877887 polymorphism and cancer risk in the Chinese population.Methods We searched all relevant studies published on association between the let-7 rs10877887 polymorphism and cancer risk in PubMed,Embase and Wanfang databases up to December 31,2016 were searched.A total of 4 case-control studies comprising 2 754 cases and 3 481 controls were included in this meta-analysis.The pooled odds ratio (OR) and 95% confidence interval (95%CI) were calculated to examine the strength of the association.Sensitivity analyses were performed to assess the stability of the results,publication bias was also assessed.Results The pooled results showed that there was a significant association between the let-7 rs10877887 polymorphism and overall cancer risk under the dominant model (CC+CT vs.TT:OR=0.90,95%CI=0.82-1.00,P=0.048).Conclusion Base on present studies,the results of this meta-analysis indicated that there is a significant association between the let-7 rs10877887 polymorphism and overall cancer risk in the Chinese population,the let-7 rs10877887 polymorphism could decrease the risk of cancer.
