Correlative study on thrombelastogram and hemorrhagic transformation after acute ischemic stroke

VernacularTitle:血栓弹力图与急性脑梗死后出血性转化的相关性研究
Author: Yanru CHEN ; Haiyan LUO
Keywords: brain infarction; hemorrhagic transformation; thrombelastogram; risk factor
From: International Journal of Laboratory Medicine 2017;38(8):1040-1042
CountryChina
Language:Chinese
Abstract: Objective To investigate the correlation between indexes of thrombelastogram (TEG) and hemorrhagic transformation (HT) after acute ischemic stroke.Methods The cases of acute ischemic stroke but not receiving early reperfusion therapy were recruited in our hospital from January to November 2016,and were divided into HT group and non-HT group.Their general clinical characteristics and TEG indexes were retrospectively analyzed,and comparison between two groups and multivariate Logistic regression analysis were performed.Results A total of 71 cases were enrolled and 11 of them were divided into HT group.The percentages of massive cerebral infarction and cardio-embolic stroke were significantly higher in HT group than those in non-HT group (P<0.05),whereas the levels of CI in HT group were significantly lower than thoes in non-HT group(P<0.05).Multivariate Logistic regression analysis showed that massive cerebral infarction (OR=13.172,95%CI:1.414-122.671) and CI(OR=0.554,95%CI:0.321-0.956) were independently correlated with HT(P<0.05).Conclusion CI is independently correlated with HT after acute ischemic stroke,and may be a potential predictor of HT.