Evaluation of procalcitonin and endotoxin in early diagnosis and prognosis in critically ill patients with sepsis
10.3969/j.issn.1673-4130.2017.08.013
- VernacularTitle:降钙素原与内毒素在危重症患者脓毒症早期诊断及预后的价值研究
- Author:
Yijian LI
;
Zongmian ZHANG
;
Kuncheng WANG
;
Xiaowen YUAN
- Keywords:
procalcitonin;
endotoxin;
sepsis;
prognosis
- From:
International Journal of Laboratory Medicine
2017;38(8):1045-1047
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the value of procalcitonin(PCT) and endotoxin(ET) in early diagnosis and prognosis in critically illness patients with sepsis.Methods A total of 104 cases with suspected sepsis were prospectively collected in this study from February 2015 to October 2016 in ICU.There were 31 cases of systemic inflammatory response syndrome (SIRS group),30 cases of sepsis 24 cases of severe sepsis and 19 cases of septic shock.Prognosis was observed in patients with sepsis discharged,57 cases were survival (survival group) while 16 cases were dead (death group).The level of PCT and ET and the clinical characteristics were recorded,The the ROC curve was applied to evaluate the discriminative power of variables.Results The levels of PCT,APACHE-Ⅱ score,ET of cases with sepsis,severe sepsis and septic shock were significantly higher than those in SIRS group(P<0.05).The PCT and APACHE-Ⅱ scores were elevated by the severities of disease (P<0.05).ROC curve analysis showed that,the sensitivity of PCT value was 82.2% and specificity was 87.5%.PCT and APACHE-Ⅱ scores were higher in the death group (P<0.05),whereas there was no significant difference on ET between the two groups (P>0.05).ROC curve showed that AUC of PCT was 0.867,which was significantly higher than that for APACHE-Ⅱ score (AUC=0.762) (P>0.05).Conclusion Compared with APACHE-Ⅱ score and ET,PCT can help clinicians to early diagnose and treat cases with sepsis.
