Treatment strategies for relapsed and refractory multiple myeloma
10.3760/cma.j.issn.1008-6315.2017
- VernacularTitle:复发难治性多发性骨髓瘤的治疗进展
- Author:
Hongmei ZHANG
- Keywords:
Relapsed;
Refractory;
Multiple myeloma;
New drug;
Stem cell transplantation
- From:
Clinical Medicine of China
2017;33(2):179-183
- CountryChina
- Language:Chinese
-
Abstract:
The prognosis for patients multiple myeloma(MM)has improved substantially over the past decade with the development of new,more effective chemotherapeutic agents and regimens that possess a high level of anti-tumor activity.In spite of this important progress,however,nearly all MM patients ultimately relapse,even those who experience a complete response to initial therapy.This summarize provided detailed recommendations on management of relapsed disease,with sections dedicated to diagnostic evaluation,determinants of therapy,and general approach to patients with specific disease characteristics.In addition,the article provided a summary of evidence from clinical trials that have significantly impacted the field,including those evaluating conventional therapies,as well as both autologous and allogeneic stem cell transplantation.Finally,perspective is provided regarding new agents and promising directions in management of relapsed MM.
