The relationship research between β2-microglobulin and D-Dimer concentration and kidney injury in pregnancy-induced hypertension patients

VernacularTitle:尿β2微球蛋白及D-二聚体与妊娠期高血压肾脏损伤的相关性研究
Author: Benxia ZHOU ; Min YAN
Keywords: β2-microglobulin; D-Dimer; pregnancy-induced hypertension; NADPH oxidase; kidney injury
From: International Journal of Laboratory Medicine 2017;38(8):1069-1071
CountryChina
Language:Chinese
Abstract: Objective To explore the relationship between β2-microglobulin and D-Dimer concentration in the pregnancy-induced hypertension patients with kidney injury.Methods The 120 cases of kidney injury pregnancy-induced hypertension patients were enrolled in our hospital from Nov 2010 to Nov 2015 (served as observation group).The levels of BUN,Scr,UA,β2-microglobulin and D-Dimer were detected.The 100 cases of healthy subjects and 120 cases of normal pregnancy women were taken as controls,respectively.Results Compared with healthy control and normal pregnancy women,the levels of BUN,Scr,UA were increased significantly in the observation group (P<0.05).The results also showed that the expression of NGAL,NLRP3,NADPH oxidase subunits,TGFβ,Smad2,Smad3,β2-microglobulin and D-Dimer were sharply increased as compared with the other two group (P<0.05).Conclusion β2-microglobulin and D-Dimer are significantly related with pregnancy-induced hypertension patients with kidney injury and they would be taken as clinical indicators for the diagnosis of this disease.