Corn silk extract improves benign prostatic hyperplasia in experimental rat model.
10.4162/nrp.2017.11.5.373
- Author:
So Ra KIM
1
;
Ae Wha HA
;
Hyun Ji CHOI
;
Sun Lim KIM
;
Hyeon Jung KANG
;
Myung Hwan KIM
;
Woo Kyoung KIM
Author Information
1. Department of Food Science and Nutrition, Dankook University, 119, Dandae-ro, Dongnam-gu, Cheonan-si, Chungnam 31116, Korea. wkkim@dankook.ac.kr
- Publication Type:Original Article
- Keywords:
Prostate;
testosterone;
Zea mays;
finasteride;
maysin
- MeSH:
Animals;
Dihydrotestosterone;
Finasteride;
Humans;
Injections, Subcutaneous;
Male;
Models, Animal*;
Orchiectomy;
Proliferating Cell Nuclear Antigen;
Prostate;
Prostate-Specific Antigen;
Prostatic Hyperplasia*;
Rats*;
Rats, Wistar;
RNA, Messenger;
Silk*;
Testosterone;
Testosterone Propionate;
Zea mays*
- From:Nutrition Research and Practice
2017;11(5):373-380
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/OBJECTIVES: This study was conducted to investigate the effect of a corn silk extract on improving benign prostatic hyperplasia (BPH). MATERIALS/METHODS: The experimental animals, 6-week-old male Wistar rats, were divided into sham-operated control (Sham) and experimental groups. The experimental group, which underwent orchiectomy and received subcutaneous injection of 10 mg/kg of testosterone propionate to induce BPH, was divided into a Testo Only group that received only testosterone, a Testo+Fina group that received testosterone and 5 mg/kg finasteride, a Testo+CSE10 group that received testosterone and 10 mg/kg of corn silk extract, and a Testo+CSE100 group that received testosterone and 100 mg/kg of corn silk extract. Prostate weight and concentrations of dihydrotestosterone (DHT), 5α-reductase 2 (5α-R2), and prostate specific antigen (PSA) in serum or prostate tissue were determined. The mRNA expressions of 5α-R2 and proliferating cell nuclear antigen (PCNA) in prostate tissue were also measured. RESULTS: Compared to the Sham group, prostate weight was significantly higher in the Testo Only group and decreased significantly in the Testo+Fina, Testo+CSE10, and Testo+CSE100 groups (P < 0.05), results that were consistent with those for serum DHT concentrations. The concentrations of 5α-R2 in serum and prostate as well as the mRNA expression of 5α-R2 in prostate were significantly lower in the Testo+Fina, Testo+CSE10, and Testo+CSE100 groups than that in the Testo Only group (P < 0.05). Similarly, the concentrations of PSA in serum and prostate were significantly lower in the Testo+Fina, Testo+CSE10, and Testo+CSE100 groups (P < 0.05) than in the Testo Only group. The mRNA expression of PCNA in prostate dose-independently decreased in the Testo+CSE-treated groups (P < 0.05). CONCLUSIONS: BPH was induced through injection of testosterone, and corn silk extract treatment improved BPH symptoms by inhibiting the mRNA expression of 5α-R2 and decreasing the amount of 5α-R2, DHT, and PSA in serum and prostate tissue.
