Analysis of the biological effects of dose radiotherapy for primary liver cancer patients with stereotactic body portion
10.3760/cma.j.issn.1008-6706.2017.10.005
- VernacularTitle:原发性肝癌患者应用立体定向体部放射治疗的生物效应剂量分析
- Author:
Yanping SHEN
;
Jun CHEN
;
Linrong PANG
;
Youhui WANG
;
Hui LI
- Keywords:
Liver neoplasms;
Radiotherapy dosage
- From:
Chinese Journal of Primary Medicine and Pharmacy
2017;24(10):1458-1461
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the biological effects of dose radiotherapy for primary liver cancer patients with stereotactic body portion.Methods 80 patients with primary liver cancer were selected.According to a random number table method, all patients were divided into observation group and control group,40 patients in each group.All patients were treated with stereotactic body radiotherapy treatment, the observation group was treated with high dose, while the control group received low-dose.The radiotherapy effects of different doses were analyzed and compared.Results After treatment, the effective rate of the observation group was 77.5%,which of the control group was 55.0%, ,the difference between the two groups was statistically significant (x2=4.528,P=0.033).After treatment for 6 months,1 year and 2 years, the survival rates of the observation group were 77.5%,75.0%,72.5%, which were significantly higher than 55.5%,52.5%,50.0% of the control group (P<0.05).The incidence rate of adverse reactions of the observation group was 42.5%, which was significantly lower than 72.5% of the control group (x2=7.365,P=0.006).Conclusion Stereotactic body radiotherapy treatment with different therapeutic dose has different treatment efficacy, high-dose SBRT treatment has significantly higher efficacy, survival rate and lower adverse reactions, which is worthy of clinical application.
