Clinical research of bilevel non-invasive mechanical ventilation in the treatment of chronic obstructive pulmonary disease with respiratory failure
10.3760/cma.j.issn.1008-6706.2017.10.025
- VernacularTitle:双水平无创正压机械通气治疗慢性阻塞性肺疾病并呼吸衰竭的临床研究
- Author:
Fei ZHU
;
Huayi WU
- Keywords:
Ventilators;
mechanical;
Positive-pressure respiration;
Pulmonary disease;
chronic obstructive;
Respiratory insufficiency
- From:
Chinese Journal of Primary Medicine and Pharmacy
2017;24(10):1536-1539
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the application of bilevel non-invasive mechanical ventilation in the treatment of chronic obstructive pulmonary disease(COPD) with respiratory failure.Methods 126 COPD patients with type Ⅱ respiratory failure were selected and divided into control group and research group,63 cases in each group.The control group received regular treatment,and the research group received bilevel non-invasive mechanical ventilation on the basis of regular treatment.,The results of blood gas analysis,respiratory frequency(RR),heart rate(HR) and expiratory flow(PEF) were observed and compared between the two groups.Results The indicators of pH,PaCO2,PaO2 in the research group after treatment were (7.41±0.08),(51.26±12.13)mmHg,(77.28±15.34)mmHg,which in the control group were (7.26±0.07),(67.21±13.05)mmHg,(69.26±14.31)mmHg,compared with before treatment,pH and PaO2 of the two groups were increased,PaCO2 was decreased after treatment,and the three indicators of the research group were changed significantly better than those of the control group,the differences were statistically significant(t=11.2,7.11,3.03,all P<0.01).After treatment,HR and PR of the two groups were decreased,PEF was increased.The three indicators of the research group were also changed significantly better than those of the control group,the differences were statistically significant(t=3.13,8.58,5.45,all P<0.01).Conclusion Bilevel non-invasive mechanical ventilation in the treatment of COPD with respiratory failure has remarkable clinical effects,can significantly improve the patients' blood gas analysis index,HR,RR and PEF,and it is worthy of clinical application.
