Observation of clinical effect and adverse reaction of hydromorphone for continuous epidural analgesia after cesarean section
10.3760/cma.j.issn.1008-6706.2017.10.034
- VernacularTitle:氢吗啡酮用于剖宫产术后硬膜外持续镇痛的临床效果和不良反应观察
- Author:
Zhonghua LI
;
Lixia LAN
- Keywords:
Cesarean Section;
Analgesia;
Epidural;
Hydromorphone;
Morphine;
Ropivacaine
- From:
Chinese Journal of Primary Medicine and Pharmacy
2017;24(10):1571-1574
- CountryChina
- Language:Chinese
-
Abstract:
Objective To learn the clinical effect and adverse reaction of hydromorphone for continuous epidural analgesia after cesarean section,and to provide effective anesthesia method for clinical.Methods 116 cases of cesarean section were randomly divided into observation group(65 cases) and control group(51 cases),continuous epidural analgesia was used in the two groups after operation.Among them,hydromorphone + ropivacaine was used for the observation group,morphine + ropivacaine was used for the control group.The analgesic effect and sedation degree of the two groups were evaluated.The adverse drug reactions were observed,and satisfaction of the patients after the operation was investigated.Results 6,9,24 hours after operation,the VAS pain scores of the observation group were lower than those of the control group,the differences were statistically significant(t=3.236,4.970,2.547,all P<0.05).3,6,9,24,48 hours after surgery, the differences of Ramsay sedation score between the two groups were not statistically significant(t=0.717,1.502,0.714,1.051,0.589,all P>0.05).The difference of postoperative first exhaust time between the two groups was not statistically significant(t=0.730,P>0.05).The satisfaction degree of the observation group was significantly higher than that of the control group,the difference was statistically significant(t=2.301,P<0.05).The incidence rate of adverse reactions of the observation group was 7.69%,which of the control group was 11.76%,the difference was not statistically significant(x2=0.552,P>0.05).Conclusion For continuous epidural analgesia after cesarean section,hydromorphone can effectively relieve the pain after operation,the safety of the process is high,and it has good clinical application value.
