Comparison of curative effect between r-tPA application and urokinase in the interventional therapy for acute and severe pulmonary embolism
10.3969/j.issn.1005-1678.2017.04.015
- VernacularTitle:r-tPA与尿激酶对急性高危型肺栓塞的介入治疗效果比较
- Author:
Dan CHENG
;
Hong WANG
;
Zongan LIANG
- Keywords:
acute and severe pulmonary embolism;
thrombolytic therapy;
tissue plasminogen activator;
urokinase-type plasminogen activator
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(4):46-48
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the different curative effect between r-tPA application and urokinase in the interventional therapy for acute and severe pulmonary embolism.Methods Analyzed the clinical date of 22 cases acute and severe pulmonary embolism patients,and classified them into two groups according to the application of r-tPA and urokinase to compare the changes of their blood pressure,heart rate,arterial partial pressure of oxygen,hemachrome and pulmonary arterial pressure before and after therapy,meanwhile,record the thrombolysis time that the two groups took.Results The thrombolysis effect time adopting urokinase was remarkably longer than that thrombolysis adopting r-tPA(P<0.05); The blood pressure,heart rate,arterial partial pressure of oxygen of the two groups gained remarkable improvement after therapy(P<0.05).The pulmonary arterial pressure of the urokinase group dropped obviously after operation(P<0.05),while the r-tPA group dropped not so significantly after operation.The hemachrome of the two groups did not dropped significantly after operation.Conclusion The r-tPA and urokinase are both effective to interventional therapy for acute and severe pulmonary embolism,while r-tPA can clearly shorten the time in thrombolysis and could reduce any bleeding risk.
