Effect of modified Tongyou decoction combined with FOLFOX4 chemotherapy on pre-thrombus state of patients with advanced prostatic cancer
10.3969/j.issn.1005-1678.2017.04.019
- VernacularTitle:通幽汤加减联合FOLFOX4方案对晚期前列腺癌患者前血栓状态的影响
- Author:
Teng TENG
;
Ying LIANG
;
Ligang REN
;
Yongjiang WU
- Keywords:
prostatic cancer;
chemotherapy;
prothrombotic state;
Tongyou decoction;
curative effect
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(4):59-62
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the effect of modified Tongyou decoction combined with FOLFOX4 chemotherapy on pre-thrombus state and curative effect of patients with advanced prostatic cancer.Methods 142 patients with advanced prostatic cancer were collected,all patients were randomly divided into study group and control group,71 cases in each group.The control group was given FOLFOX4 chemotherapy and the study group was given modified Tongyou decoction on the baseis of the control group.After treatment,the serum levels of homocysteine(Hcy),D-two dimer(D-D),fibrinogen(FIB),the level of hemorrheology,clinical effect,the incidence of venous thrombosis in one years,the six month survival rate,the one year survival rate were detected in all patients.Resutls After treatment,compared with control group,the serum levels of Hcy,D-D,FIB,the whole blood high,middle and low-shear viscosities,plasma viscosity and the incidence of venous thrombosis in one years were higher in the study group and the difference was statistically significant(P<0.05);the erythrocyte deformability index,effective rate and one year survival rate were higher were higher in the study group and the difference was statistically significant(P<0.05).Conclusion The modified Tongyou decoction combined with FOLFOX4 chemotherapy in treatment of patients with advanced prostatic cancer can improve the prethrombotic state,improve the therapeutic effect,reduce the incidence of venous thrombosis and increase the one year survival rate,and have a guiding significance for clinic.
