Effect of Fukeqianjin tablets on uterine bleeding patients serum immunoglobulin IgM, IgA, IL-2 in serum and its soluble receptor function
10.3969/j.issn.1005-1678.2017.04.023
- VernacularTitle:妇科千金片联合孕激素对功能性子宫出血患者血清免疫球蛋白IgM、IgA、血清IL-2及其可溶性受体的影响
- Author:
Chunyue WANG
;
Ning LI
;
Xinya XU
;
Qi YE
- Keywords:
functional uterine bleeding;
immunoglobulin;
inflammatory factor;
Fukeqianjin tablets
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(4):72-74
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Fukeqianjin tablets combined with progesterone on serum immunoglobulin,serum IL-2 and soluble receptor levels in patients with functional uterine bleeding,and to explore the optimal regimen for patients with functional uterine bleeding.Methods A total of 98 patients with functional uterine bleeding diagnosed in our hospital from June,2015 to June,2016 were randomLy divided into observation group and control group(n=49).The patients in the control group were treated with oral progesterone and the observation group.The control group was treated on the basis of the combination of gynecological Qianjin Tablet,compared the two groups of patients before and after treatment of menstrual conditions,serum IgM,IgA,serum IL-2 and soluble receptor levels.Results In the first month,the second month and the third month after treatment,the menstrual volume in the observation group were(103.5±21.5)mL,(93.5±14.7)mL,(81.4± 12.2)(7.68±0.92)d,(6.81±0.87)d and(6.14±0.78)d respectively in the observation group were significantly shorter than those in the control group(P<0.05).After treatment,the menstrual period The serum levels of IgA and IgM were(3.6±0.8),(2.6±0.8),(1.8±0.3)and(2.9±0.5),(2.2±0.3),(1.1±0.2)in the first month,the second month and the third month respectively,Significantly lower than the control group,the difference was statistically significant; the first month after treatment,the first two months,the first three months,observation group of patients with serum IL-2 and soluble receptor levels significantly Lower than the control group.Conclusion Fukeqianjin tablets combined with progesterone can improve the immune function of patients with functional uterine bleeding,reduce the level of inflammation and soluble receptor levels,compared with single progesterone treatment better,the program better.