Clinical evaluation of xinqin granule combined with loratadine in treatment of allergic rhinitis and its effects on serum EOS, CSF and TNF-α
10.3969/j.issn.1005-1678.2017.04.026
- VernacularTitle:辛芩颗粒联合氯雷他定用于变应性鼻炎的临床评价及对患者血清EOS、CSF、TNF-α水平的影响
- Author:
Xuesong NING
;
Linlin HOU
- Keywords:
allergic rhinitis;
Xinqin granule;
loratadine;
laboratory index
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(4):81-83
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study clinical evaluation of xinqin granule combined with loratadine in treatment of allergic rhinitis and its effects on serum eosinophil(EOS),colony stimulating factor(CSF)and tumor necrosis factor(TNF)-α.Methods 90 patients of allergic rhinitis who received therapy from January 2014 to November 2016 in our hospital were selected.According to random number table,those patients were divided into the observation group(n=45)and the control group(n=45).The control group was treated with loratadine,while the observation group was combined with xinqin granule.Then the serum EOS,CSF and TNF-α,symptom score,clinical efficacy and adverse reactions were compared.Results After treatment,the serum levels of EOS,CSF and TNF-αin the observation group were significantly lower than that of the control group(P<0.05); the symptom score in the observation group was significantly lower than that of the control group(P<0.05); the total effective rate in the observation group was significantly higher than that of the control group[93.33％(42/45)vs.73.33％(33/45)](P<0.05); there was no significant difference in the incidence of adverse reactions between the two groups.Conclusion Xinqin granule combined with loratadine is well for allergic rhinitis,which can effectively reduce serum levels of EOS,CSF,TNF-α,relieve clinical symptoms,it's worthy of application and promotion.
