Effect of Huachansu capsule combined with hepatic arterial infusion chemotherapy on plasma fibrinogen and tumor marker boncentration in patients with Hepatocellular carcinoma
10.3969/j.issn.1005-1678.2017.04.031
- VernacularTitle:华蟾素胶囊联合肝动脉灌注化疗栓塞对肝癌患者血浆纤维蛋白原、肿瘤标志物浓度的影响
- Author:
Lifeng XIA
;
Buzhuo LI
;
Haijun WU
;
Xiaoping XU
- Keywords:
cinobufotalin capsule;
hepatic arterial infusion chemoembolization;
liver cancer
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(4):97-99
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of cinobufotalin capsule combined with transcatheter arterial chemoembolization in patients with hepatocellular carcinoma.Methods 68 patients with hepatocellular carcinoma from January,2013 to March,2016 were selected and divided into the combination group and chemotherapy group according to the random number table method,each with 34 cases.The combination group was treated with transcatheter arterial chemoembolization and hepatic artery infusion chemotherapy embolization.The levels of D-dimer,tumor markers,clinical efficacy and quality of life scores were observed before and after treatment in 68 patients.Results There was no significant difference in plasma fibrinogen(FIB)in combination group before and after treatment.Before treatment,the levels of FIB)was similar to chemotherapy group.After treatment,the FIB content in the chemotherapy group was significantly higher than before treatment and that in the combination group the differences were statistically significant(P<0.05).After treatment,the levels of cytokeratin 19,carcinoembryonic antigen and neuron-specific enolase in two group were significantly higher than those before treatment(P<0.05).But there was no significant difference between the two groups after treatment.The rate of disease control in the combination group was significantly higher than that in the chemotherapy group(77.5％vs.65.4％,P<0.05).Cases of diarrhea and insomnia in chemotherapy group were similar to the combination group,but the differences of cases of pain and fatigue between two group were statistically significant(P<0.05).Conclusion Cinobufotalin capsule combined with transcatheter arterial chemoembolization can improve the hypercoagulability of the patient's blood,and is beneficial to the treatment of cancer,improve the disease control rate and improve the life of patients.
