Effect of fluconazole capsules combine with Zhibai dihuangwan on serum IL-10, TNF-α and clinical effect on trichomonas vaginitis patients
10.3969/j.issn.1005-1678.2017.04.041
- VernacularTitle:氟康唑胶囊联合知柏地黄丸对滴虫性阴道炎患者血清IL-10,TNF-α及临床疗效的影响
- Author:
Fenping WANG
;
Jun WANG
- Keywords:
fluconazole capsules;
Zhibaidihuang wan;
trichomonas vaginitis;
IL-10;
TNF-α
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(4):128-130
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the fluconazole capsule combined with Zhibaidihuangwan on Trichomonas vaginitis patients on serum IL-10,TNF-α and clinical effect.Methods 78 cases of trichomonas vaginitis patients were collected in our hospital,randomly divided into two groups: experimental group and control group,with 39 cases in each.After admission,the patients in the control group received fluconazole 0.2g,onetimes aday; patients in the experimental group on the basis of the control group given Zhibai dihuangwan eight pills/time,threetimes a day,continuous treatment for fourweeks.Observation and comparison of two groups of patients before and after treatment of interleukin-10(IL-10),tumor necrosis factor alpha(TNF-α),the patient's vaginal health score and the level of clinical efficacy.Results compared with before treatment,IL-10,TNF-α levels were decreased after treatment of the two groups,the difference is statistically significant(P<0.05); Compared with the control group,IL-10,TNF-α is low of patients in the experimental group,the difference has statistical significance(P< 0.05);Compared with before treatment,the patients in the two groups of vagina health score were significantly increased after treatment,the difference is statistically significant(P<0.05); Compared with the control group,the vagina health score is higher in experimental group patients,the difference is statistically significant(P< 0.05); Compared with the control group,the the total efficiency is higher of patients in the experimental group,the difference is statistically significant(P<0.05).Conclusion fluconazole capsule combined with Zhibaidihuangwan can reduce trichomonad vaginitis patients serum IL-10,TNF-α levels,improve clinical symptoms,clinical curative effect is better.
