Progress in Diagnosis and Treatment of Hereditary Diffuse Gastric Cancer
10.3969/j.issn.1008-7125.2017.04.002
- VernacularTitle:遗传性弥漫性胃癌的诊治进展
- Author:
Yujie ZHANG
;
Yongquan SHI
- Keywords:
Stomach Neoplasms;
Diffuse Gastric Cancer;
Heredity;
Cadherins;
CDH1 Gene;
Mutation;
Diagnosis;
Therapy
- From:
Chinese Journal of Gastroenterology
2017;22(4):199-202
- CountryChina
- Language:Chinese
-
Abstract:
Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant inherited disease,and may be related to the mutation of CDH1 or CTNNA1 genes.Microscopically,signet-ring cell carcinoma is suggested frequently in endoscopic biopsy or gastrectomy specimens.Some patients may have concomitant extra-stomach tumor (frequently breast cancer in females).Detection of CDH1 gene mutation should be performed in high-risk individuals,and diagnosis and treatment should be carried out by a multidisciplinary team.Prophylactic gastrectomy is recommended for those with pathogenic CDH1 mutation.Endoscopic surveillance is an option for those with CDH1 mutation of undetermined significance and those without germline CDH1 mutation.This review discussed the concept,genetic characteristics,clinicopathological features and genetic screening of HDGC for providing a reference for clinicians.
