Platelet Count/Spleen Diameter Ratio for Prediction of Esophageal Varices in Patients with HBV-related Cirrhosis: A Clinical Study
10.3969/j.issn.1008-7125.2017.04.005
- VernacularTitle:血小板计数与脾脏长径比值预测慢性乙型肝炎肝硬化食管静脉曲张的临床研究
- Author:
Jinhui LI
;
Xiang CHEN
;
Xiujuan YAN
;
Hai LI
;
Shengliang CHEN
- Keywords:
Platelet Count;
Spleen Diameter;
Esophageal and Gastric Varices;
Hepatitis B;
Chronic;
Liver Cirrhosis;
Prediction
- From:
Chinese Journal of Gastroenterology
2017;22(4):214-217
- CountryChina
- Language:Chinese
-
Abstract:
Background: Esophageal variceal bleeding is a clinical emergency and the major cause of death in patients with liver cirrhosis.Aims: To assess the value of platelet count (PC)/spleen diameter (SD) ratio in predicting the presence of esophageal varices (EV) in patients with HBV-related cirrhosis in China.Methods: A total of 91 consecutive HBV-related cirrhosis patients with EV from Aug.2013 to Dec.2015 at Renji Hospital (South Campus),School of Medicine,Shanghai Jiao Tong University were enrolled.Thirty-two HBV-related cirrhosis patients without EV were enrolled as controls.Upper gastrointestinal endoscopy,routine laboratory examinations and abdominal ultrasonography were performed and the related parameters were collected.Binary Logistic regression analysis was carried out to identify independent risk factors associated with EV.ROC curve was used to evaluate the predictive performance of PC/SD ratio for the presence of EV.Results: The PC/SD ratio was significantly lower in EV group than in non-EV group (538.2±327.0 vs.1 105.9±426.6,P=0.001).Binary Logistic regression analysis showed that the PC/SD ratio was independently associated with the presence of EV (OR=57.29,95％ CI: 15～214,P=0.000).In ROC curve analysis,the area under the curve (AUC) of PC/SD ratio in predicting the presence of EV was 0.853;the optimal cutoff value was 842,and the sensitivity,specificity,positive predictive value and negative predictive value were 85.7％,75.0％,90.7％,and 64.9％,respectively.Conclusions: PC/SD ratio can be used as a non-invasive tool for prediction of the presence of EV in patients with HBV-related cirrhosis.It may reduce the number of unnecessary endoscopy.
