Preliminary research on functional polymer liposome-entrapped gold nanoparticles as CT contrast agents
10.3969/j.issn.1005-1678.2017.04.002
- VernacularTitle:功能化高分子脂质体包裹的纳米金颗粒作为新型CT造影剂的初步研究
- Author:
Yanyan GUO
;
Yajuan LIU
;
Lin WANG
;
Huan LI
;
Jin CHANG
;
Xiaodong LI
- Keywords:
gold nanoparticles;
polymer liposome;
CT imaging;
contrast agent;
molecular probes
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(4):5-8
- CountryChina
- Language:Chinese
-
Abstract:
Objective To research the functional polymer liposome-trapped gold nanoparticles as molecular probes used as CT contrast agents.Methods Gold nanoparticles were entrapped by ultrasonic micro-emulsion method using self-developed linoleic acid-modified dextran polymer liposome.Under the same concentrations,clinical imaging was performed with Iohexol as control for the analysis of CT value differences.Then,the particle suspensions at appropriate concentration(6 mg/mL)were intravenously injected into Balb/c nude mice for real-time observation of CT imaging.ResultsIn vitro results showed that nanoparticles at greater than 4 mg/mL could present much higher CT value than Iohexol at the same conditions,while in vivo studies indicated nanoparticles could clearly show different organ contrast with prolonged circulation time.Conclusion Compared to clinical contrast agent Iohexol,functional polymer liposome entrapped gold nanoparticles could possess a great application prospect to be used as a new type of molecular probes for CT enhanced imaging.
