Effect of bifidobacteria combined with zinc on serum CRP level and clinical efficacy in children with diarrhea
10.3969/j.issn.1005-1678.2017.04.012
- VernacularTitle:双歧三联活菌联合锌剂对小儿腹泻患者血清hs-CRP水平及临床疗效的影响
- Author:
Xueqin WU
;
Aizhong MA
;
Xiaoping LU
- Keywords:
children diarrhea;
bifidobacteria;
zinc agent;
CRP;
IL-10;
IL-6
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(4):37-39
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of the levels of serum high sensitive C reactive protein and its clinical effect by bifidobacteria combined zinc in the treatment children with diarrhea.Methods 100 children with diarrhea from June 2013 to June 2016 in our hospital were selected and randomly divided into the control group and the experiment group,50 cases in the control group were get general routine treatment,such as dehydration and zinc supplement,50 cases in the experiment group were treated on the base of the control group with bifidobacteria.The clinical curative effect,the disappearance time of clinical symptoms of diarrhea and the level of serum high sensitive C reactive protein(CRP),interleukin-10(IL-10)and interleukin-6(IL-6)were observed and compared between two groups.Results After treatment,the total effective rate of the treatment group was higher than that of the control group,the clinical symptoms disappeared earlier than the control group,the difference was statistically significant(P<0.05).The serum CRP,IL-10 and IL-6 levels were lower than before treatment and the experiment group was more lower,the difference was statistically significant(P<0.05).Conclusion The clinical efficacy and recovery time of the combined application ofbifidobacteria and zinc in children with diarrhea is related to the decrease of serum CRP,IL-10 and IL-6 levels.
