Effect of Xuefuzhuyu pill on blood glucose, sex hormone, insulin level and HOMA-IR index in infertile women caused by polycystic ovary syndrome
10.3969/j.issn.1005-1678.2017.04.039
- VernacularTitle:血府逐瘀丸对多囊卵巢综合征所致不孕女性血糖、性激素、胰岛素水平及HOMA-IR指数的影响
- Author:
Qian SONG
;
Li YE
;
Yan LI
- Keywords:
Xuefuzhuyu pill;
polycystic ovary with infertility;
blood sugar;
sex hormone;
insulin resistance
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(4):121-124
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Xuefuzhuyu pill on blood glucose,sex hormone,insulin levels and HOMA-IR index in patients with polycystic ovary syndrome and infertility.Methods 59 patients with polycystic ovary syndrome and infertility from January 2014 to January 2015 in our hospital were selected and randomly divided into experimental group and control group,29 cases in each group,the control group was treated with clomiphene citrate capsules,the patients in the experimental group were given Xuefuzhuyu pill baseed on the treatment in control group,treatment period for three menstrual cycles,after the end of treatment,the levels of serum sex hormone levels,fasting blood glucose,insulin levels,HOMA index,uterine endometrial thickness,ovulation and pregnancy were detected.Results After treatment,compared with control group,in the experimental group,the serum levels of LH and T were significantly lower,and the serum levels of FSH,E2 and P were significantly higher,the difference was statistically significant(P<0.05),the serum anti-Mullerian hormone(AMH)content in the experimental group was significantly lower,the difference was statistically significant(P<0.05),the serum levels of FINS and HOMA-IR were significantly lower in the experimental group,the difference was statistically significant(P<0.05),the endometrial thickness of patients in experimental group was significantly increased,the number of follicles and ovarian volume were significantly decreased,the difference was statistically significant(P<0.05),the ovulation rate and pregnancy rate in the experimental group was higher,the difference was statistically significant(P<0.05).Conclusion Xuefuzhuyu pill can significantly reduce the serum LH,T,FINS,AMH and HOMA-IR levels in patients with polycystic ovary syndrome,which can improve the serum FSH,P,E2 levels,regulate sex hormone secretion,reduce insulin resistance,improve the ovulation rate and pregnancy rate,compared to single use of citric acid clomiphene capsules effect is more ideal.
