Cytotoxicity of Ibuprofen Raw Material and its Part of Impurities
- VernacularTitle:布洛芬原料药及部分杂质的细胞毒性研究
- Author:
Yang WANG
;
Kaiyong HE
;
Jiate SHEN
;
Yating YANG
- Keywords:
Ibuprofen;
Impurity;
Cytotoxicity
- From:
China Pharmacist
2017;20(4):769-771
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the cytotoxicity of ibuprofen and its 6 kinds of impurities.Methods:Different concentrations of ibuprofen and the impurities were used to act on mouse fibroblasts (L929) for 72 h,and the cytotoxicity was observed under a microscope.Results:In ibuprofen raw material,the cytotoxicity of impurity B was the weakest with slight toxicity,the cytotoxicity of impurity N,D,J and V was moderate,and that of impurity E was severe.Conclusion:At the same concentration,the toxicity of impurity E is the strongest,and its content in ibuprofen preparations should be strictly controlled.
