Efficacy and safety of phosphoric acid phosphate combined metformin in the treatment of diagnosis of type 2 diabetes mellitus
10.3969/j.issn.1005-1678.2017.04.065
- VernacularTitle:磷酸西格列汀联合二甲双胍对新诊断2型糖尿病临床疗效及安全性研究
- Author:
Haiyan YAN
;
Ming ZHAO
;
Chun LUO
- Keywords:
phosphoric acid phosphate;
metformin;
type 2 diabetes;
clinical study;
safety
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(4):198-200
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of phosphoric acid phosphate combined metformin in the treatment of diagnosis of type 2 diabetes mellitus.Methods A total of 86 cases with diagnosis of type 2 diabetes mellitus included in this study were dividing into control group and experiment group with each 43 cases.The patients in the both groups were give regular treatment.Patients in the control group were given metformin hydrochloride sustained release tablets 500mg by oral administration with 3 times a day and patients in the experiment group revieved phosphoric acid phosphate by oral administration with once a day.A cycle of 2 groups of patients were 28d,a total of 3 cycles of treatment.The ADP,APAF1,D25-(OH)D3),CysC and adverse drug reactions were compared between the two groups.Results The clinical efficacy in experiment group was 93.02％,which significant higher than that in control group 76.74％(P<0.05).The serum level of ADP,APAF1 and CysC decreased after treatment with experiment group much lower than the control group(P<0.05).The serum D25-(OH)D3l elevated in the two groups with experiment group much higher than the control group(P<0.05).The adverse drug reactions was not statistically different between the two groups.Conclusion Phosphoric acid phosphate combined metformin in the treatment of diagnosis of type 2 diabetes mellitus was effective with high safety.
