Study on application of tranexamic acid in perioperative period of intertrochanter fracture of femur
10.3969/j.issn.1005-1678.2017.04.089
- VernacularTitle:氨甲环酸应用于股骨粗隆间骨折围手术期的临床疗效评价
- Author:
Yongwei LU
;
Yinhai WANG
;
Lianhua GU
- Keywords:
intertrochanter fracture of femur;
perioperative period;
tranexamic acid;
volume of blood loss;
application
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(4):268-270
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the application of tranexamic acid in perioperative period of intertrochanter fracture of femur.Methods 46 cases of patients with intertrochanter fracture of femur were randomLy divided into the control group and treatment group,23 cases in each group.All patients underwent partial hip replacement,10min before operation,the control group was given 0.9％sodium chloride injection100mL,intravenous drip; the experimental group was treated with tranexamic acid injection 10mg/kg,soluble in 100mL 0.9％sodium chloride injection,intravenous drip;Before and after operation,compared between the two groups of patients with blood t hematocrit(HCT),hemoglobin(Hb)levels,volume of blood loss,volume of blood transfusion and incidence of postoperative complications.Results After operation,compared with the control group,the serum levels of HCT、Hb were higher in the experimental group(P<0.05).The total blood loss,hidden blood loss,intraoperative blood loss,postoperative drainage volume and blood transfusion volume were lower in the experimental group(P<0.05).There was no significant difference in the incidence of complications between the 2 groups.Conclusion The tranexamic acid can significantly reduce the volume of blood loss and volume of blood transfusion in perioperative period of patients with intertrochanter fracture of femur,and do not increase the incidence of postoperative complications of thrombosis,and have high security.
