Efficacy of alprostadil injection combined the octreotide for acute severe pancreatitis and influence on the serum levels of TNF-α, IL-6, IL-18, occludin
10.3969/j.issn.1005-1678.2017.04.107
- VernacularTitle:前列地尔注射液联合奥曲肽治疗急性重症胰腺炎的疗效及对患者血清TNF-α、IL-6、IL-18、闭合蛋白水平的影响
- Author:
Honghui CAI
;
Xiaomei DENG
- Keywords:
acute severe pancreatitis;
alprostadil injection;
octreotide;
curative effect;
tumor necrosis factor-α;
occludin;
interleukin-6;
interleukin-18
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(4):323-325
- CountryChina
- Language:Chinese
-
Abstract:
Objective To research the efficacy of alprostadil injection combined the octreotide for acute severe pancreatitis and influence on the serum levels of tumor necrosis factor-α(TNF-α),interleukin-6,interleukin-18,occludin.Method 68 cases of patients with acute severe pancreatitis from September 2013 to February 2017 in our hospital,according to the treatment method group,34 cases in each group,control group treatmented by octreotide,the research group based on the control group treatmented by alprostadil injection,both groups was treated for five days.Clinical curative effect,alleviate clinical symptoms time,TNF-α,IL-6,IL-18,occludin,and adverse reactions occur was compared between two groups.Results The total effective rate of research group was higher than the control group(97.07％vs.79.41％,P<0.05).Bowel sounds,stomach ache,body temperature and serum amylase remission time of research group was shorter than control group(P<0.05).TNF-α,IL-6,IL-18 of research group was lower than the control group(P<0.05),the occludin of research group was higher than the control group(P<0.05).The adverse reactions was no differences between the two groups.Conclusion The exact effect of alprostadil injection combined the octreotide for acute severe pancreatitis,improve serum levels of TNF-α,IL-6,IL-18,occludin.
