Clinical effect analysis of blood coagulation therapy in patients with gastric ulcer bleeding treated by omeprazole and Agkistrodon acutus venom and changes of serum vascular endothelial growth factor and epidermal growth factor levels in serum
10.3969/j.issn.1005-1678.2017.04.111
- VernacularTitle:奥美拉唑与蝮蛇血凝酶针对胃溃疡血清血管内皮生长因子、上皮生长因子水平变化及临床疗效分析
- Author:
Aimin ZHANG
;
Zhihong LIN
;
Jiangfeng DAI
- Keywords:
gastric ulcer;
hemorrhage;
hemagglutination enzyme
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(4):336-338
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effect of coagulation therapy in patients with gastric ulcer bleeding.Methods From January 2013 to January 2016 in Xiaoshan First People's hospital 150 cases of gastric ulcer patients with bleeding,using SPSS16.0 software to generate randomly divided into hemocoagulase group(basic treatment + hemocoagulase injection therapy)and control group(basic treatment)of the 75 cases,compared two groups of hemostatic time,hemostatic effect.Results After 72h treatment,the average hemostasis time of hemocoagulase group were significantly lower than the control group(P<0.05),the blood coagulation enzyme in patients with serum VEGF,EGF levels higher than the control group(P<0.05),gastrin and somatostatin levels lower than the control group(P<0.05),hemocoagulase group cure rate is 64％,effective in 22.67％,effective 9.33％,invalid 4％,the control group were 46.67％,25.33％,18.67％,9.33％,two groups compare difference was statistically significant(P<0.05).Conclusion Treatment of gastric ulcer bleeding patients with coagulation enzyme can shorten the hemostatic time,improve the clinical effect of hemostasis.
