Preventive effect of octreotide combined with netilmicin sulfate on postoperative infection in suppurative appendicitis and its effect on Th17/Treg imbalance
10.3969/j.issn.1005-1678.2017.04.116
- VernacularTitle:奥曲肽联合硫酸奈替米星预防化脓性阑尾炎术后感染及对患者Th17/Treg失衡的影响
- Author:
Songjing ZHANG
;
Xiangxiang MA
;
Ke ZHANG
- Keywords:
suppurative appendicitis;
octreotide;
netilmicin sulfate;
helper T cell 17;
regulatory T cell
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(4):351-353
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the preventive effect of octreotide combined with netilmicin sulfate on postoperative infection in suppurative appendicitis and its effect on helper T cell 17(Th17)/regulatory T cells(Treg)imbalance.Methods 148 patients with acute suppurative appendicitis in Xiangshan Hospital of Traditional Chinese Medicine from August 2014 to May 2016 were randomly divided into observation group(n=74)and control group(n=74).All were underwent laparoscopic appendectomy surgery,the control group took netilmicin sulfate combined with ornidazole for anti-infection after operative,while the observation group added octreotide acetate subcutaneously.The levels of serum interleukin(IL)-4,IL-6,IL-10,IL-17,IL-23,transforming growth factor β(TGF-β),interferon γ(IFN-γ)and Th17,Treg cell ratio and expression levels of related transcription factorbefore and after treatment were detected,Th17/Treg change were analyzed.Results The levels of IL-4,IL-6,IL-10,IL-17,TGF-β were decreased,IFN-γ were increased after treatment(P<0.01),the improvement of those indicators in the observation group were supior than control group(P<0.05).Th17,Treg cell ratio and expression levels of related transcription factor orphan nuclear receptorγt(RORγt),Forkhead box protein P3(Foxp3)were decrease,Th17/Treg was reduced after treatment(P<0.01),those indexes in observation group were lower than those in control group(P<0.05).The wound infection,intra-abdominal infections and other adverse events had no significant difference in two groups.Conclusions Octreotide combined with netilmicin sulfate can prevent postoperative infection in suppurative appendicitis,regulate Th17/Treg imbalance,restore immune function,and no significant adverse reactions.
