Clinical effects and adverse reactions of oral azithromycin and oral and vein erythromycin in the treatment of respiratory tract infection in children
10.3969/j.issn.1005-1678.2017.04.124
- VernacularTitle:口服阿奇霉素、口服及静脉红霉素治疗呼吸道支原体感染疗效及不良反应对比
- Author:
Yanxiong ZHAO
;
Sulin SHI
;
Shanshan LIU
- Keywords:
infection of respiratory tract;
mycoplasma;
azithromycin;
erythromycin
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(4):376-378
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare and analyze the clinical effect and adverse reaction of oral azithromycin,oral and intravenous erythromycin on the treatment of mycoplasma infection in respiratory tract.Methods In our hospital in January 2015～March 2016 year,clinical datas of 110 cases with mycoplasma infection in respiratory tract in children were analyzed retrospectively.The total cases were randomly divided into the oral azithromycin treatment group(38 cases),oral erythromycin treatment group(36 cases)and erythromycin intravenous group(36 cases).The therapeutic effects and the adverse reactions were evaluated in the three groups.ResultsThe effective rate in the oral azithromycin group was significantly higher than that of the two other groups.The time of fever fading,rales and cough disappearance and the hospitalized day in the the oral azithromycin group were significantly shorter than that in the other two groups.Serum IL-8,TNF-alpha and hs-CRP level and the adverse reaction rate in the the oral azithromycin was significantly lower than that in the other two groups.The differences of all above the indexes were statistically significant(all P<0.05),the above index in the oral erythromycin group and erythromycin intravenous group was no statistical significance.Conclusion Compared with different medication route of erythromycin,it can get better results which oral azithromycin was used on the treatment of children with respiratory tract mycoplasma infection,the adverse reactions rate is lower,is a safe and effective treatment.
