Two-versus three-dimensional speckle tracking technology in assessing anthracycline-induced cardiotoxicity in patients with breast cancer
10.3969/j.issn.1006-5725.2017.03.032
- VernacularTitle:二维和三维斑点追踪技术评价蒽环类药物对乳腺癌患者心脏毒性的对比研究
- Author:
Songyu LIU
;
Ling WANG
;
Jie CHEN
;
Jianqiong CHEN
- Keywords:
Speckle tracking echocardiography;
Breast cancer;
Ventricular function,left;
Anthracyclinc
- From:
The Journal of Practical Medicine
2017;33(3):451-454
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the toxicity of anthracyclinc to left ventricle function in patients withbreast cancer,and to compare the clinical values between two-dimensional speckle tracking echocardiography (2D-STE) and 3D-STE.Methods 50 patients with breast cancer who had received surgical treatment and epirubicinbased chemotherapy were recruited to study groups.All the patients had undergone up to 6 cycles of chemotherapy.Different stages wcre identified according to accumulated doses of epirubicin reaching 0 mg/m2,120 mg/m2,240 mg/m2 and 360 mg/m2.2D-STE and 3D-STE parameters were measured before chemotherapy and after different stage of chemotherapy.The receiver operating characteristics curves (ROC) of parameters (2D-GLS,3D-GLS,3D-GCS,3DGAS) were graphed to evaluate the specificity and sensitivity of detecting dysfunction of the left ventricles.25 healthy volunteers were recruited to a control group.Results As compared with the control group and the baselines,2D-GLS and 3D-GCS was significantly declined (P < 0.05),3D-GAS and 3D-GLS were significantly lowered after interim period and later period (P < 0.05),while 3D-GRS was not changed significantly during the whole chemotherapy period.The ROC curves revealed the sensitivity of 2D-GLS,3D-GCS,3D-GLS and 3D-GAS for assessing dysfunction of the left ventricles was 60.7%,65.3%,62.7%,and 80.7%,while the specificity was 50.0%,54.0%,64.0%,and 82.0%,respectively.Conclusions As compared with 2D-STE,3D-STE can detect the dysfunction of left ventricles earlier and more accurately.Furthermore,the specificity and sensitivity of 3D-GAS are the highest among all parameters in detecting the early dysfunction of left ventricles.