Clinical comparative of aspirin and clopidogrel combined with atorvastatin calcium in the treatment of acute ischemic cerebrovascular disease
10.3969/j.issn.1005-1678.2017.01.045
- VernacularTitle:阿司匹林与氯吡格雷联合阿托伐他汀钙治疗急性缺血性脑血管病患者的疗效比较
- Author:
Jianlong CHEN
;
Peitao YU
- Keywords:
acute ischemic cerebrovascular disease;
aspirin;
clopidogrel;
atorvastatin calcium
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(1):157-159
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical effects of aspirin and clopidogrel combined with atorvastatin calcium in patients with acute ischemic cerebrovascular disease. Methods 27 cases of patients with acute ischemic cerebrovascular disease from March 2015 to March 2016 in Hainan general hospital were selected,and randomly divided into control group and observation group,13 patients in the control group,treated with aspirin and clopidogrel,14 cases in the observation group,treat with atorvastatin calcium based on the control group,both two groups were treatment for three months.The total effective rate were compared between the two groups after treatment,NIHSS score and serum lipid level were compared before and after treatment. Results After treatment,the total effective rate of observation group was 92.9%,significantly higher than the control group 53.8%(P<0.05).Compared with before treatmeng,the NIHSS score of two groups were decreased,the levels of TC,TG and LDL-C in two groups were decreased,HDL-C was increased (P<0.05);Compared with control group,the NIHSS score of observation group was lower,TC,TG and LDL-C were lower,HDL-C was higher (P<0.05). Conclusion Aspirin and clopidogrel combined with atorvastatin calcium in treatment with acute ischemic cerebrovascular disease has significant effect,can reduce the patient's NIHSS score,improve blood lipid levels.
