Research progress of pigment epithelium-derived factor ,insulin resistance and type 2 diabetes
10.3969/j.issn.1006-6187.2017.03.017
- VernacularTitle:色素上皮衍生因子与胰岛素抵抗及2型糖尿病的研究进展
- Author:
Yanxin XIAO
;
Jun WANG
- Keywords:
Pigment epithelium-derived factor(PEDF);
Insulin resistance(IR);
Diabetes mellitus;
type 2;
Diabetic microangiopathy;
Diabetic macroangiopathy
- From:
Chinese Journal of Diabetes
2017;25(3):277-280
- CountryChina
- Language:Chinese
-
Abstract:
Pigment epithelium-derived factor (PEDF ) was originally found fromretinal pigment epithelium. It is confirmed that it plays an anti-angiogenic and apoptosis role in diabetic microangiopathy. Recently ,PEDF has been found to have a close relationship with insulin resistance ,type 2 diabetes and diabetic macroangiopathy. But the mechanism is unclear. More and more researches focused on its role in oxidative stress. PEDF may become a new target for diabetes and diabetic complication treatment and also a predictive factor for the disease.
