Dexamethasone sodium phosphate injection combined with spinal and epidural anesthesia in delivery of elderly parturient women
10.3969/j.issn.1005-1678.2017.01.079
- VernacularTitle:地塞米松磷酸钠注射液联合腰硬麻醉在高龄产妇分娩中的临床意义
- Author:
Xueping DING
;
Lingling YU
;
Boxi XIA
- Keywords:
dexamethasone sodium phosphate injection;
combination;
spinal and epidural anesthesia;
elderly parturient women;
delivery;
tramadol
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(1):263-265
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical significance of dexamethasone (DT) in the combined spinal and epidural anesthesia for delivery of elderly parturient women. Methods 134 elderly parturient women were selected as the research object, and randomly divided into two groups. 69 cases in DT group received intramuscular injection of dexamethasone and combined anesthesia, while 65 cases in INN group received intramuscular injection of tramadol (INN) and combined spinal and epidural anesthesia. The anesthetic effect of the two groups were observed. Results After treatment, the interleukin (IL-6), myeloperoxidase (MPO), tumor necrosis factor-α (TNF-α) and methane dicarboxylic aldehyde (MDA) in DT group were significantly higher than INN group (P<0.05). The five kinds of immunoglobulins levels (IgA, IgD, IgE, IgG and IgM) in DT group were higher than those in INN group (P<0.05). The heart rate (HR) in DT group was lower and mean arterial pressure (MAP) was higher than that in INN group(P<0.05). There was 1 cases of macrosomia, 2 cases of premature delivery in DT group, the adverse pregnancy outcomes was 4.35%(3/69). there was 1 cases of macrosomia, 1 cases of congenital deformity, 1 cases of premature delivery and 1 case of postterm delivery in DT group, the adverse pregnancy outcomes was 5.80%(4/69), with no significant difference between two groups. Conclusion Dexamethasone combined with anesthesia is very effective for delivery of elderly parturient women which shows very good anti-inflammatory and immunoregulation.
