Application of cerebrolysin in pediatric clinic
10.3969/j.issn.1005-1678.2017.01.094
- VernacularTitle:脑蛋白水解物在儿科临床中的应用
- Author:
Mingqian ZHAO
;
Yongyao MAI
;
Yi LIU
;
Xiangjun DENG
;
Lin CHEN
;
Guohua CHENG
;
Ting WANG
- Keywords:
cerebrolysin;
clinical application;
hypoxic-ischemic encephalopathy;
infantile cerebral palsy;
drug combination
- From:
Chinese Journal of Biochemical Pharmaceutics
2017;37(1):315-318
- CountryChina
- Language:Chinese
-
Abstract:
Cerebrolysin is an aqueous mixture of amino acids extracted from porcine brain, and mainly composed of 85% free amino acids and 15%small peptides. Cerebrolysin increase the metabolism of amino acids and glucose transport in the brain, improve the anti-anoxia ability of cells, and to enhance the brain's resistance to various types of malignant stimulation like stress and damage. Cerebrolysin can also promote synapse formation, induce neuronal differentiation, and help reverse brain injury. Because of its efficacy and safety, cerebrolysin has been widely used in the pediatric clinical practice, and primarily to treat neonatal hypoxic ischemic encephalopathy, childcerebral palsy, hyperactivity disorder, speech communication disorders, etc.The clinical symptoms were improved to some extent after the treatment of cerebrolysin. The recovery of consciousness, enhancement of comprehensionand memory, and improvement of the extremity motor function were observed. The treatment of cerebrolysincan not only enhance the cure rate, but also reduce the incidence of sequelae. This paper systematically summarized the clinical application of cerebrolysin in the pediatric population and relevant preclinical studies, to provide more guidance for clinical application of cerebrolysin in the treatment of pediatric diseases.
