Analysis of hepatitis associated aplastic anemia in 5 children
10.3969/j.issn.1000-3606.2017.04.004
- VernacularTitle:儿童肝炎相关再生障碍性贫血5例分析
- Author:
Xiang LI
;
Xiaoming ZHAO
;
Guangyao SHENG
- Keywords:
hepatitis;
aplastic anemia;
child
- From:
Journal of Clinical Pediatrics
2017;35(4):256-258
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical feature, treatment and prognosis of hepatitis associated aplastic anemia (HAAA) in children. Method The clinical data of 5 children with HAAA were retrospectively analyzed. Results There were 5 patients (4 males and 1 female) with median age of 10 years (7~13 years ). The detection of hepatitis A, B, C, and E were all negative in these 5 children during their acute hepatitis period. In 2 children, parvovirus B19 antibody and EB virus were negative and the proportion of CD4+T cells and the ratio of CD4+/CD8+ were decreased, and the proportion of CD8+T cells was increased by T-lymphocyte subsets analysis. Three children were treated with anti-thymocyte globulin combined with cyclosporine, 2 of whom achieved complete remission and 1 died of pulmonary fungal infection. One child was treated with cyclosporine only and achieved partial remission. One child lost follow-up after giving up treatment. Conclusion HAAA in children can be caused by viral seronegative hepatitis, and usually has T lymphocyte immune disorders. Immunosuppressive therapy is effective. .
