Systemic lupus erythematosus combined with antiphospholipid syndrome and cerebral thrombosis in a child: a case report and literature review

VernacularTitle:儿童系统性红斑狼疮合并抗磷脂综合征及脑血栓1例报告并文献复习
Author: Wei PAN ; Chenli LI ; Hongbing CHEN
Keywords: systemic lupus erythematosus; antiphospholipid syndrome; antiphospholipid antibody; cerebral thrombosis; child
From: Journal of Clinical Pediatrics 2017;35(4):293-295
CountryChina
Language:Chinese
Abstract: Objective To explore the clinical features of systemic lupus erythematosus (SLE) combined with antiphospholipid syndrome (APS) and cerebral thrombosis in a child. Method The clinical data of SLE combined with APS and cerebral thrombosis in a child was retrospectively analyzed, and the related literature was reviewed. Results This was a 12-year-old boy. The disease onset with recurrent fever, confusion and rash in cheek. He had anemia and thrombocytopenia, and positive antinuclear antibody (ANA) and anticardiolipin antibody (aCL). Magnetic resonance imaging showed multiple cerebral infarction. The diagnosis of SLE combined with APS and cerebral thrombosis was clearly made. Methylprednisolone, cyclophosphamide, warfarin, meropenem and acyclovir were used for the treatment. At the same time, the patient also received intravenous immunoglobulin. Conclusion SLE combined with APS and cerebral thrombosis in children was usually in a severe condition, the prognosis of which can be effectively improve by early diagnosis and reasonable treatment.