Research Progress in Relationship Between Treating Steroid-induced Osteonecrosis of Femoral Head by Deficiency and OPG/RANK/RANKL

VernacularTitle:"从""虚""论治激素性股骨头坏死与OPG/RANK/RANKL系统相关性研究进展"
Author: Linzhong CAO ; Xiaogang ZHANG ; Xiyun ZHAO ; Min SONG ; Hongwei ZHANG ; Daping QIN ; Xiaoming WANG
Keywords: steroid-induced osteonecrosis of femoral head; OPG/RANK/RANKL system; spleen and kidney deficiency; review
From: Chinese Journal of Information on Traditional Chinese Medicine 2017;24(4):123-126
CountryChina
Language:Chinese
Abstract: Recent studies have shown that TCM treatment for bone metabolic diseases, such as steroid-induced avascular necrosis of the femoral head, has definite efficacy and has received extensive attention. However, due to lack of molecular biological basis of pharmacodynamics mechanism, it has not yet reached the standard of scientific treatment. The discovery of OPG/RANK/RANKL system has become a new breakthrough point in the prevention and treatment of bone metabolic diseases. The pathogenesis of deficiency of spleen and kidney - blood stasis - caused by phlegm arthralgia caused by blood stasis is closely related to the system. The effect of the final control of the system from the deficiency theory can be expressed through the axial micro-information. This article discussed the TCM syndrome differentiation of steroid-induced osteonecrosis of the femoral head and the relation of regulation of bone metabolism combined with the OPG/RANK/RANKL system, and provided the basis for prevention and treatment of this disease.