Transcription factors EB and Parkinson's disease
10.3969/j.issn.1001-1978.2017.03.003
- VernacularTitle:转录因子EB与帕金森病
- Author:
Xinmei HAO
;
Yujuan LI
- Keywords:
transcription factors EB;
Parkinson's disease;
auto-phagy;
lysosome;
α-synuclein;
mTOR
- From:
Chinese Pharmacological Bulletin
2017;33(3):305-308
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy is a powerful process for removing such proteins and for maintaining homeostasis.However,autophagy dysfunction has also been implicated in the pathogenesis of vari-ous neurodegenerative diseases,including Parkinson 's disease (PD).Recent studies have shown that TFEB could regulate au-tophagy and lysosome function through regulating the expressionof the relatedgenes.Thus,TFEB plays a key role in the occur-rence of Parkinson's disease.Therefore,this article will make a review of the regulatory mechanism of TFEB and its role in Par-kinson's disease.
