Value of combined detection of serum IL-8 ,TNF-α,KL-6 and SP-D in assisted diagnosis of idiopathic pulmonary fibrosis
10.3969/j.issn.1673-4130.2017.05.021
- VernacularTitle:联合检测血清IL-8,TNF-α,KL-6、SP-D在特发性肺纤维化辅助诊断中的价值
- Author:
Shu HUANG
;
Wenqian ZHAI
;
Shuyuan QIAN
- Keywords:
interleukin-8;
tumor necrosis factor-α;
alvedar cell surface antigen Ⅱ;
surface protein D;
idiopathic pulmo-nary fibrosis
- From:
International Journal of Laboratory Medicine
2017;38(5):628-630
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical value of combined detection of serum interleukin(IL)-8 ,tumor necrosis factor(TNF)-α,alvedar cell surface antigen Ⅱ(KL-6) and surface protein D(SP-D) in the diagnosis of idiopathic pulmonary fibrosis(IPF) .Meth-ods Seventy three patients with IPF were selected as the research subjects ,other 73 patients with bacterial pneumonia were taken as the bacterial pneumonia group .The levels of serum IL-8 ,TNF-α,KL-6 and SP-D were detected by enzyme-linked immunosorbent assay (ELISA) .The serum levels of IL-8 ,TNF-α,KL-6 and SP-D were compared between the IPF group and bacterial pneumonia group .The sensitivity and specificity of IPF detection were compared between the 4-index combined detection and single item de-tection .Results The levels of IL-8 ,TNF-α,KL-6 and SP-D in the IPF group were significantly higher than those in the bacterial pneumonia group (P<0 .05) .The positive rate of single detection of four indexes in the IPF group was significantly higher than that in the bacterial pneumonia group (P<0 .05) .The sensitivity and specificity of the 4-index combined detection for diagnosing IPF were 90 .4% and 93 .2% respectively ,which were significantly higher than the those of single index detection (P<0 .05) .Con-clusion The combined detection of IL-8 ,TNF-α,KL-6 and SP-D has better sensitivity and specificity in IPF diagnosis compared with single detection of IL-8 ,TNF-α,KL-6 and SP-D .
