Clinical significance of interleukin -17,18,32 and lung adenocarcinoma antigen in evaluating the severity of acute exacerbations of COPD
10.3760/cma.j.issn.1008-6706.2017.05.008
- VernacularTitle:白细胞介素17、白细胞介素18、白细胞介素32及肺腺癌抗原评估慢性阻塞性肺疾病急性加重期病情严重程度的临床价值
- Author:
Fuquan QI
- Keywords:
Pulmonary Disease,Chronic Obstructive;
Interleukin-17;
Interleukin-18;
Interleukin-32;
Tumor Antigen
- From:
Chinese Journal of Primary Medicine and Pharmacy
2017;24(5):672-675
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between the expression of IL -17,18,32 as well as the lung adenocarcinoma antigen KL -6 and the severity of patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD).Methods Totally 120 AECOPD patients treated in our hospital (Zhejiang Rongjun Hospital) form Jan 2014 to Jan 2016 were selected.Among them,the condition of 50 cases got controlled after treatment(group A),while other 70 cases did not get controlled(group B).At the same time,26 healthy people were selected as control group.The expression levels of IL -17,18,32 and KL -6 in the blood of there groups were detected by ELISA.Results The IL -17,18,32,KL -6 levels of group A were (49.07 ±17.22)pg/mL,(156.38 ±24.41)pg/mL, (11.63 ±4.05)pg/mL,(106.62 ±13.74)pg/mL,which were significantly higher than those of the control group [(32.32 ±3.04)pg/mL,(134.83 ±18.92)pg/mL,(9.26 ±3.35)pg/mL,(65.24 ±15.51 )pg/mL,t =4.905, 3.926,3.561,11.916,all P <0.05].The IL -17,18,32,KL -6 levels of group B were (92.68 ±13.25)pg/mL, (357.44 ±26.35)pg/mL,(50.10 ±9.88)pg/mL,(285.64 ±25.40)pg/mL,which were significantly higher than those of group A,the differences were statistically significant between the two groups (t =15.674,42.479,25.995, 45.293,all P <0.05 ).Conclusion The expression levels of IL -17,18,32 and lung adenocarcinoma antigen KL -6 are elevated with the increased severity of AECOPD patients.Therefore,the expression levels of these four indicators can be used to evaluate the severity of AECOPD patients.
