Expression of BRG1 in colon cancer and its relationship with histological grade and clinicopathological stages characteristics
10.3760/cma.j.issn.1008-6706.2017.05.011
- VernacularTitle:结肠癌组织中 BRG1的表达及其与病理分级、临床病理分期的相关性
- Author:
Lei QIU
;
Hua SHAO
;
Jianwu DENG
;
Yongchang MIAO
- Keywords:
Colonic Neoplasms;
Genes,BRG1;
Pathology,clinical
- From:
Chinese Journal of Primary Medicine and Pharmacy
2017;24(5):683-685
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of BRG1 gene in colon cancer and its relationship with histological grade and clinicopathological stages characteristics.Methods The expression of BRG1 -positive cancer cells were detected by immunohistochemistry in 100 cases of colon cancer,and the relationship with histological grade and clinicopathological stages characteristics was analyzed.Results Of the 100 colon cancer specimens analyzed,the positive expression rate was 82.0%.The expression of BRG1 in colon cancer tissue with histological grade and TNM staging was significantly different (χ2 =23.509,P =0.024;χ2 =25.659,P =0.002).The higher the histological grade,the stronger the BRG1 expression in colon cancer tissue.BRG1 expression in advanced colon cancer tissue was significantly enhanced in the early stage.Conclusion The appearance of BRG1 -positive cancer cells is associated with histological grade and clinicopathological stages characteristics.BRG1 might play an important role in the development of colon cancer.
