The relationship between genetic polymorphisms of key enzymes in folate metabolism and nonsyndromic cleft of lip with or without palate
10.16571/j.cnki.1008-8199.2017.03.019
- VernacularTitle:叶酸代谢关键酶基因多态性与非综合征性唇腭裂相关性研究进展
- Author:
Tao YAO
- Keywords:
Nonsyndromic cleft of lip with or without palate;
Folate metabolism;
Key enzyme;
Gene polymorphism
- From:
Journal of Medical Postgraduates
2017;30(3):310-314
- CountryChina
- Language:Chinese
-
Abstract:
Nonsyndromic cleft of lip with or without palate ( NSCL/P ) is one of the most common congenital birth defects in the maxillofacial region and it is related to genetic factors and environment .Folic acid deficiency , metabolic disorder and the genetic polymorphisms of key metabolic enzymes may be the important factors contributing to NSCL /P .Maternal folic acid intake may reduce the risk of non syndrome cleft lip and palate .This article will review the relationship among the metabolism of folic acid , the genetic polymorphisms of key enzymes in folate metabolism and NSCL /P .
