Seroepidemiology of Epstein Barr virus in men who have sex with men in Chongqing area

Xin Dai; Li Chen; Jiajun LI; Wenxiang Huang; Ailong Huang; Xiaoni Zhong

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Seroepidemiology of Epstein Barr virus in men who have sex with men in Chongqing area

VernacularTitle:重庆地区男男性行为者人群EB病毒血清流行病学调查
Author: Xin DAI ; Li CHEN ; Jiajun LI ; Wenxiang HUANG ; Ailong HUANG ; Xiaoni ZHONG
Keywords: men who have sex with men; Epstein Barr virus; infection; viral reactivation
From: Chinese Journal of Infection and Chemotherapy 2017;17(2):148-152
CountryChina
Language:Chinese
Abstract: Objective To investigate the seroepidemiology of Epstein-Barr virus (EBV) and human immunodeficiency virus (HIV) in adult men who have sex with men (MSM) in Chongqing area. Methods Nonprobability sampling method was used to test EB-CA-IgG, EB-NA-IgG and EB-VCA-IgM in the sera of 1082 MSMs from the clinical trials of HIV/AIDS treatments in Chongqing area from 2012 to 2015, and 1059 healthy individuals by means of enzyme-linked immunosorbent assay. The results were analyzed by Chi-square test. The difference was considered statistically significant when P<0.05. Results The 1082 MSM included 130 HIV positive and 952 HIV negative subjects. The prevalence of prior EBV infection was 92.6% in total MSM population, 88.5% in HIV-positive MSM, and 93.2% in HIV-negative MSM. The prevalence in total MSM and HIV negative MSM was significantly higher than that in control group (89.9%). Prior EBV infection was not?found?in?0.5%?of?the?total?MSM,?0.8%?of?HIV?positive?MSM?and?0.4%?of?HIV?negative?MSM,?all?significantly?lower?than?that?of control group (5.0%) (P<0.05).?Finally,?the?rate?of?EBV?reactivation?in?HIV?positive?MSM?(10.0%)?was?significantly?higher?than?that in control group (3.8%) and in HIV negative MSM group(4.1%) (P<0.005). Conclusions EBV infection is highly prevalent in MSM, higher than that in the general population. The rate of EBV reactivation in HIV negative MSM is similar to that in general population. The rate of seroepidemiology-based EBV reactivation is significantly higher in HIV positive MSM, which may be associated with the immunocompromised status post HIV infection.