Advances in Research on Toxic Side Effects and Mechanism of Drugs Induced by Enterohepatic Cycle
10.3870/j.issn.1004-0781.2017.03.014
- VernacularTitle:具有肝肠循环特征药物诱发的毒副作用及其机制研究进展
- Author:
Guangyi YANG
;
Chenning ZHANG
;
Rongjiao ZHANG
;
Jinbao WEI
;
Weidong MA
;
Yonghong ZHANG
- Keywords:
Enterohepatic cycle;
Prototype drug;
Two-phase metabolism;
Toxic side effect
- From:
Herald of Medicine
2017;36(3):299-302
- CountryChina
- Language:Chinese
-
Abstract:
The enterohepatic circulation is an important form of drug absorption and excretion.Drugs with enterothepatic circulation can induce toxic side effects,and elucidate the mechanism of induced side effects is a necessary understanding of the phenomenon of adverse drug reaction.Enterohepatic circulation of drugs involves in two ways:one is based on the drug prototype for enterohepatic circulation;the other is phase Ⅱ metabolic pathway for enterohepatic circulation.In this paper,two kinds of enterohepatic circulation were reviewed.The toxic side effects of six kinds of drugs with enterohepatic circulation were introduced,and the possible mechanism were described and discussed,so as to have contributed to more rational use of drugs in clinical practice.Furthermore,it can promote the research and development of new drugs.
