Clinical analysis of 4 patients with Aspergillus tracheobronchitis
10.16718/j.1009-7708.2017.01.003
- VernacularTitle:曲霉气管支气管炎4例临床分析
- Author:
Weiye ZHAO
;
Jing LIU
;
Xuedong LIU
- Keywords:
Aspergillus;
bronchitis;
bronchoscopy;
diagnosis;
treatment
- From:
Chinese Journal of Infection and Chemotherapy
2017;17(1):19-23
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical manifestations, auxiliary examination, diagnosis and therapy of Aspergillus tracheobronchitis (ATB).Methods Clinical data of 4 ATB patients treated in Qingdao Municipal Hospital from June 2012 to September 2015 were analyzed retrospectively. The related literature was also reviewed.Results The main clinical manifestations were cough, sputum production, short of breath, fever and hemoptysis. All the four patients had predisposing factors. The ifndings of CT scan mainly included bronchial wall thickening, obstruction of bronchial lumen or no significant abnormality. Bronchoscopy showed mucosal erosion, necrosis, tracheal stenosis and obstruction of airway by pseudo-membrane. The diagnosis was confirmed by histopathology in all the four cases. They were treated with anti-Aspergillus therapy. The two patients with airway stenosis were treated with interventional therapy via bronchoscope. As for the outcome, one patient was improved after therapy. Another was cured. The remaining two patients died.Conclusions The clinical manifestations and chest imaging of ATB are nonspecific. Bronchoscopy is an important tool for diagnosis of ATB. Early diagnosis and proper anti-Aspergillus treatment are critical for improving prognosis.
