Functions and characteristics of calcium-sensing receptorsand effects of CaSR on characteristics of adult stem cells
10.3969/j.issn.1001-1978.2017.04.005
- VernacularTitle:钙敏感受体的功能特点及对成体干细胞特性的影响
- Author:
Xin LUO
;
Limei YU
- Keywords:
calcium sensing receptor;
G-protein coupled receptors;
cell signaling pathway;
hematopoietic stem cell;
mesenchymal stem cell;
ginsenoside Rg1;
cinacalcet
- From:
Chinese Pharmacological Bulletin
2017;33(4):465-468
- CountryChina
- Language:Chinese
-
Abstract:
Calcium-sensing receptor(CaSR) is a widely distributed G-protein coupled receptor.The activated CaSR plays an important role in many kinds of signaling pathway regulation, such as Ca2+ signaling pathway.It not only maintains the body calcium balance, but also is involved in the regulation of a variety of cell secretion, proliferation, apoptosis, and ion channel opening processes.CaSR expression is involved in stem cell migration, adhesion and homing in hematopoietic stem cells and mesenchymal stem cells.The activated CaSR also regulated the function of itself and characteristics in stem cells through a variety of cell signaling pathways.We introduce the functions and characteristics of CaSR, the relationship between CaSR and disease, and review the effects of the biological characteristics on hematopoietic stem cells and mesenchymal stem cells.
