Clinical Presentations of 36 Cases of Antithyroid Drug-induced Agranulocytosis
10.11969/j.issn.1673-548X.2017.03.022
- VernacularTitle:抗甲状腺药物治疗导致粒细胞缺乏症36例患者临床资料分析
- Author:
Xiaofeng CHAI
;
Xiaolan LIAN
- Keywords:
Agranulocytosis;
Antithyroid drugs;
Methimazole;
Propythiouracil;
Granulocyte clony-stimulating factor
- From:
Journal of Medical Research
2017;46(3):87-90
- CountryChina
- Language:Chinese
-
Abstract:
Objective In this article,we report and discuss the clinical presentation of antithyroid drug(ATD)-induced agranulocytosis.Methods We retrospectively studied 36 cases of ATD-induced agranulocytosis over the past 14 years in PUMC hospital.Results ATD-induced agranulocytosis patient's age ranged of 16-62 years old.88.9％ of ATD-induced agranulocytosis occured with a large ATD treatment.91.7％ patients occured in the first three month of drug therapy.A case occured agranulocytosis when 8 months duration.94.4％ patients occurs secondary infections.Conclusion This study showed that ATD-induced agranulocytosis considered to be dose dependent,not irrelevant to sex,age and the drug.
