Study on the Anti-inflammatory, Antitussive and Analgesic Effects of Jinhua Qingre Capsules
10.3870/j.issn.1004-0781.2017.03.008
- VernacularTitle:锦花清热胶囊抗炎镇咳镇痛作用研究
- Author:
Changjiu GAO
;
Chaoli ZHANG
;
Zhujia ZHENG
;
Jiafu HOU
;
Huan LIU
;
Ting WU
;
Huiying BI
;
Guangping WANG
;
Jindan AN
;
Zhongcheng YU
- Keywords:
Jinhua qingre capsules;
Anti-inflammatory;
Antitussive;
Analgesia
- From:
Herald of Medicine
2017;36(3):268-271
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the anti-inflammatory,antitussive,and analgesia effects of Jinhua qingre capsules.Methods The anti-inflammatory effect was assessed by the methods include xylene-induced mouse auricular swelling and histamine-induced pigment oozing from skin vessel in rats;The antitussive and analgesic effect were assessed by ammonia water induced cough model and acetic acid-induced twisting method.Results In anti-inflammation experiment,the high dose (12 g·kg-1) and moderate (6 g·kg-1) groups of Jinhua qingre capsules showed significant inhibitory effect on auricular swelling and significant difference compared with control group (P ＜ 0.01,P ＜ 0.05.);the high dose (10 g· kg-1) and moderate dose (5 g·kg-1) groups of Jinhua Qingre capsules play a marked inhibitory role in the increase in mouse peritoneal capillary permeability (P ＜ 0.01,P ＜ 0.05).In antitussive experiment,high dose (12 g· kg-1) and moderate dose (6 g· kg-1) groups had significant inhibitory effect on cough caused by ammonia water (P ＜ 0.01,P ＜ 0.05) compared with control group.In analgesic experiment,the high dose (12 g·kg-1),moderate dose (6 g·kg-1),and low dose (3 g·kg-1) groups effectively reduced the writhing frequency of mice (P ＜ 0.01,P ＜ 0.05).Conclusion Jinhua qingre capsules have potential effects on anti-inflammatory,antitussive,and analgesic.
