Cross-talk of GPCRs and RTKs and its effects on oncotherapy
10.3969/j.issn.1001-1978.2017.04.003
- VernacularTitle:G蛋白偶联受体与酪氨酸激酶受体之间的信号交流在肿瘤治疗中的作用
- Author:
Luyao CHEN
;
Yang YANG
;
Shu AN
;
Xiaoxi GUO
;
Qian HAO
;
Tianrui XU
;
Ying LIU
- Keywords:
G protein coupled receptors;
receptor tyrosine kinases;
signaling crosstalk;
oncotherapy;
transactivation;
trans-regulation
- From:
Chinese Pharmacological Bulletin
2017;33(4):454-460
- CountryChina
- Language:Chinese
-
Abstract:
G protein-coupled receptors (GPCRs) are the largest cell surface receptor family, which mediates activities of almost all known cellular response to ligands, including hormones release, neurotransmitters and sensory input.GPCRs can promote development and progression of gastric cancer, colorectal cancer, lung cancer and breast cancer and other tumors.Tyrosine kinase receptors (RTKs) are another important family of membrane receptors, which can regulate cell proliferation, differentiation, migration and survival.Overexpression of RTKs has been found in many cancer cells.Therefore, GPCRs and RTKs are equally important in the clinical treatment of cancer therapeutic.However, GPCRs and RTKs are not independent, and they can use common signal transduction.The present study show that crosstalk between GPCRs and RTKs can facilitate migration of lung epithelial cells, increasing survival of nerve cells and promoting tumor occurrence and development.This article mainly focuses on crosstalk between GPCRs and RTKs and their roles in tumorigenesis and oncotherapy.
