Effect of Anti-Renin Angiotensin System Drugs in Tumors
10.3870/j.issn.1004-0781.2017.03.015
- VernacularTitle:抗肾素-血管紧张素系统药物在抗肿瘤中的作用
- Author:
Peilei LI
;
Meng GUO
;
Wenyuan GUO
- Keywords:
Renin-angiotensin system (RAS);
Angiotensin Ⅱ (Angiotensin Ⅱ,Ang Ⅱ);
Angiotensin-converting enzyme 2 (ACE2);
Angiotensin receptor 1 (AT1R);
Angiogenesis;
Tissue invasion;
Proliferation
- From:
Herald of Medicine
2017;36(3):303-307
- CountryChina
- Language:Chinese
-
Abstract:
Initially,the renin-angiotensin system (RAS) was considered to play an important role in regulating cardiovascular function and maintaining the balance of water and electrolyte.Based on this,several targeted drugs in the treatment of hypertension were developed.With the large-scale clinical apphcation of these drugs,RAS inhibitors are found to has a significant inhibitory effect on some of the tumor development,which reveals the RAS function in cell proliferation,differentiation,angiogenesis and tumor occurrence.In this paper,the important physiological ftmction of RAS in tumor occurrence and development were reviewed.
