A resting-state fMRI study on brain functional activity changes m moderate and high myopia patients using fractional amplitude of low frequency fluctuation
10.13389/j.cnki.rao.2017.0060
- VernacularTitle:应用静息态功能磁共振成像分数低频振幅技术研究中高度近视患者大脑活动的异常改变
- Author:
Yuxiang HU
;
Quan ZHOU
;
Yuping LI
;
Xiaoxuan XU
;
Yifan WU
;
Kezheng LIU
;
Minyan ZHAN
;
Xiaorong WU
- Keywords:
myopia;
resting state functional magnetic resonance imaging;
fractional amplitude of low frequency fluctuation
- From:
Recent Advances in Ophthalmology
2017;37(3):239-243
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the changes of brain function in moderate and high myopia patients using fractional amplitude of low frequency fluctuation (fALFF),and discuss the correlation between brain function changes and clinical data of patients with myopia.Methods Totally 21 moderate and high myopia patients (myopia group),and 21 healthy volunteers (normal control group) who were matched with myopia patients in age and gender,were selected to take rs-fMRI examination.The difference of fALFF of brain functional activity in patients with myopia and normal controls was compared,and the correlation between the changes of fALFF and clinical data of patients with myopia was analyzed,Results Compared with normal control group,the fALFF values of myopia group in the region of the left inferior frontal gyrus,putamen and right inferior frontal gyrus,putamen and insula were significantly lower (all P ＜ 0.05,AlphaSim corrected).However,in bilateral cingulate gyrus,bilateral anterior cingulate gyrus,left postcentral gyrus,left superior parietal lobule and region,fALFF values were increased (all P ＜ 0.05,AlphaSim corrected).Conclusion Patients with myopia are accompanied by abnormal neuronal activity in many brain areas,which may reflect the dysfunction of language understanding and attention control in myopic patients.
